A SURVEY ON HAPLOTYPING ALGORITHMS FOR TIGHTLY LINKED MARKERS
نویسندگان
چکیده
منابع مشابه
A Survey on Haplotyping Algorithms for Tightly Linked Markers
Two grand challenges in the postgenomic era are to develop a detailed understanding of heritable variation in the human genome, and to develop robust strategies for identifying the genetic contribution to diseases and drug responses. Haplotypes of single nucleotide polymorphisms (SNPs) have been suggested as an effective representation of human variation, and various haplotype-based association...
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The identification of genotyping errors is an important issue in mapping complex disease genes. Although it is common practice to genotype multiple markers in a candidate region in genetic studies, the potential benefit of jointly analyzing multiple markers to detect genotyping errors has not been investigated. In this article, we discuss genotyping error detections for a set of tightly linked ...
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One of the main topics in genomics is to determine the relevance of DNA variations with some genetic disease. Single nucleotide polymorphism (SNP) is the most frequent and important form of genetic variation which involves a single DNA base. The values of a set of SNPs on a particular chromosome copy define a haplotype. Because of its importance in the studies of complex disease association, ha...
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ژورنال
عنوان ژورنال: Journal of Bioinformatics and Computational Biology
سال: 2008
ISSN: 0219-7200,1757-6334
DOI: 10.1142/s0219720008003369